摘要

BACKGROUND:Thyroidcancerandthyroidautoimmunityareconsideredoppositeextremesofimmune-responses.However,severalstudieshavesuggestedthatthyroidcancercoexistswithautoimmunethyroiddiseaseslikeHashimotoThyroiditis(HT)andGravesdisease(GD).Wehaveshownthattheriskofdevelopingthyroidcancerishigherinpatientswithasilentformofautoimmunethyroiddisease-EuthyroidHashimotoThyroiditis-(EHT).METHODS:WeanalyzeddatafromconsecutivepatientswithGD,HT,EHTandnon-AutoimmuneThyroidDisease(Non-AITD)forthepresenceofDifferentiatedThyroidCancer(DTC).Wefurtherinvestigatedthemicroenvironment,andcellularmechanismofprotectionfromDTCinGD/EHTbyex-vivoaspiratinginfiltratesfromthyroidsamples.Wealsore-constitutedinvitrothein-vivomicroenvironmenttomimicanin-vivocontext.WeisolatedNKcellsanddifferentiatedmacrophagesintoM1andM2phenotypefromhealthyhumanperipheralbloodmonocytes.RESULTS:DTCwaslessfrequent/aggressiveinGDas



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